Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Pre-dose (trough) draw - At steady state concentration.

Collect

Plain Red. Also acceptable: Lavender (EDTA) or Pink (K2EDTA).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD Solution).

Remarks
Stability

Ambient: 2 weeks; Refrigerated: 2 weeks; Frozen: 2 weeks

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Performed

Wed, Sat

Reported

1-8 days

Reference Interval

Therapeutic range (Venlafaxine and o-Desmethylvenlafaxine) 195-400 ng/mL
Toxic range (Venlafaxine and o-Desmethylvenlafaxine) Greater than or equal to 800 ng/mL

Interpretive Data

The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Adverse effects to venlafaxine therapy may include nausea, vomiting, dizziness, tremor and blurred vision.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

80338 (Alt code: G0480)

Components

Component Test Code* Component Chart Name LOINC
2007958 Venlafaxine Serum/Plasma 9630-5
2007959 O-Desmethylvenlafaxine Serum/Plasma 9628-9
2007960 Total Venlafaxine and Metabolite S/P 62849-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Effexor
  • Effexor XR
  • Pristiq
Venlafaxine and Metabolite, Serum or Plasma